程蕴菁

職稱教授
學歷哈佛大學公共衛生學院
理學博士
研究專長失智症、認知功能、衰弱、肌少症
老年、環境、基因體流行病學研究
預防醫學
授課領域老年病學流行病學
環境暴露和人類基因組
認知功能
辦公室10055台北市徐州路17號5樓519室
分機+886-2-3366-8019
office hourby appointments
Emailkarenchen@ntu.edu.tw
ORCID0000-0002-8159-7202
個人網站https://homepage.ntu.edu.tw/~karenchen/


國際研討會演講
1) Alzheimer’s Association International Conference (AAIC)
2022/8/2: San Diego, USA; 2021/7/26: Denver, USA; 2020/7/30: Amsterdam, the Netherland;
2019/7/14: Los Angels, USA.
2) International Congress of Asian Society Against Dementia (ASAD)
2025/5: Seoul, Kora, 2024/8: Penang, Malaysia; 2023/9/29: Bandung, Indonesia; 2022/9/19:
Taipei Taiwan
獲獎經驗
1) Academic Achievement Award, National Taiwan University (2009 – present)
2) Scholar-in-Training Award, American Association for Cancer Research (AACR) (2005)
AACR Conference “Oncogenomics 2005: Dissecting Cancer through Genome Research”

現行/近五年研究計畫/專案/發表

1) Bidirectional relation of gait speed with cognition
Ying-Hao Su, Jeng-Min Chiou, Chengshi Shiu, Jen-Hau Chen, Yen-Ching Chen.
Longitudinal, bidirectional association between gait speed and cognitive function in communitydwelling non-demented older adults. Journal of the American Medical Directors Association
26(5): 10544 (May 2025). [Geriatrics & Gerontology, Rank: 23.6%]


2) A new design on robot for older adults
Jia-Hsun Lo, Han-Pang Huang,* Yen-Ching Chen, Jen-Hau Chen. Memory Robot Design: A
New Perspective from Human Brain Model and Large Language Model . IEEE Access 13: 28539-
28549 (February 2025). [Computer Science, Information Systems, Rank: 34.6%]


3) Vascular factors (Carotid Intima and Ankle-Brachial Index) can predict cognition in older
adults
Kai-Jing Yeh, Meng-Jie Sun, Shin-Joe Yeh, Sung-Chun Tang, Jeng-Min Chiou, Yen-Ching
Chen, Jen-Hau Chen. Cognition and Vascular Factors: Insights from Carotid Intima-Media
Thickness and Ankle-Brachial Index in a Cohort. Journal of Alzheimer’s Disease 104(3) (2025,
in press). [Neuroscience, Rank: 37.3%]


4) Interocular retinal asymmetry can predict the risk of cognitive frailty in older adults
Yung-Sung Lee, Yi-Ting Hsieh, Te-Hsuan Huang, Jeng-Min Chiou, Tao-Chun Peng, Yao-Lin Liu,
Jen-Hau Chen, Yen-Ching Chen. Interocular retinal asymmetry and cognitive frailty: a
prospective cohort study. Alzheimer’s & Dementia 21(2): e14437 (February 2025).  [Clinical
Neurology, Rank: 1.7%]


5) Cognitive Trajectories Before and After Stroke: A Pooled Analysis of 14 Population-Based
Cohorts
Jessica W. Lo, John D. Crawford, Darren M. Lipnicki, Richard B. Lipton, Mindy J. Katz, PierreMarie Preux, Maëlenn Guerchet, Eleonora d’Orsi, Anna Quialheiro, Cassiano Ricardo Rech,
Karen Ritchie, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Elena Rolandi, Annalisa
Davin, Michele Rossi, Steffi G. Riedel-Heller, Alexander Pabst, Susanne Röhr, Mary Ganguli,
Erin Jacobsen, Beth E. Snitz, Kaarin J. Anstey, Allison E. Aiello, Henry Brodaty, Nicole A.
Kochan, Yen-Ching Chen, Jen-Hau Chen, Pascual Sanchez-Juan, Teodoro del Ser, Meritxell
Valentí, Antonio Lobo, Concepción De-la-Cámara, Elena Lobo, Perminder S. Sachdev.
Trajectory of cognitive decline before and after stroke in 14 population cohorts. JAMA Network
Open 7(10): e2437133 (October 2024). [Medicine, General & Internal, Rank: 3.5%]


6) Dental caries, incomplete dentition, and tooth wear predict cognitive impairment in the
preclinical phase of dementia
Jung-Tsu Chen, Stephanie Tsai, Min-Huey Chen, Waranuch Pitiphat, Oranart Matangkasombut,
Jeng-Min Chiou, Ming-Lun Hang, Jen-Hau Chen, Yen-Ching Chen. Association between
oral health and cognitive impairment in older adults: insights from a six-year prospective cohort
study. Journal of Dentistry 7:105088 (August 2024). [Dentistry, Oral Surgery &
MedicineRank:4.1%]


7) Cohort profile of Taiwan Initiative for Geriatric Epidemiological Research (TIGER)
Pei-Iun Hsieh, Te-Hsuan Huang, Jeng-Min Chiou, Jen-Hau Chen, Yen-Ching Chen. Cohort
profile: the Taiwan Initiative for Geriatric Epidemiological Research – a prospective cohort study
3
on cognition. Epidemiology and Health e2024057 (June 2024). [Public, Environmental &
Occupational HealthRank:46.7%]


8) Dental caries, incomplete dentition, and tooth wear predict cognitive impairment in the
preclinical phase of dementia
Jung-Tsu Chen, Stephanie Tsai, Min-Huey Chen, Waranuch Pitiphat, Oranart Matangkasombut,
Jeng-Min Chiou, Ming-Lun Hang, Jen-Hau Chen, Yen-Ching Chen. Association between oral
health and cognitive impairment in older adults: insights from a six-year prospective cohort study.
Journal of Dentistry 47:105088 (August 2024). [Dentistry, Oral Surgery & Medicine, Rank:
4.1%]


9) Protective effect of coffee and tea consumption on Alzheimer’s disease and vascular
dementia varied by sex and vascular comorbidities
Kuan-Chu Hou, Yen-Ching Chen, Ta-Fu Chen, Yu Sun, Li-Li We, Ping-Keung Yip, Yi-Min Chu, Jeng-Min Chiou, Jen-Hau Chen. Coffee and tea consumption and dementia risk: The role
of sex and vascular comorbidities. Journal of the Formosan Medical Association 6: S0929-
6646(24)00218-3 (May 2024). [Medicine, General & Internal, Rank: 21.4%]


10) Asymmetric handgrip strength can predict cognitive impairment in older adults
Tao-Chun Peng, Jeng-Min Chiou, Ta-Fu Chen, Yen-Ching Chen, Jen-Hau Chen. Handgrip
Strength Asymmetry and Cognitive Impairment Risk: Insights from a Seven-Year Prospective
Cohort Study. Journal of Nutrition, Health and Aging. 28(1): 100004 (January 2024). [Geriatrics
& Gerontology, Rank: 25%]


11) Olfactory dysfunction may serve as an early marker for predicting cognitive impairment in
older adults
Mu-Cyun Wang, Jeng-Min Chiou, Yen-Ching Chen, Jen-Hau Chen. Association between
olfactory dysfunction and cognitive impairment in dementia-free older adults: A prospective
cohort study in Taiwan. Journal of Alzheimer’s Disease. 96(4): 1477-1488 (December 2023).
[Neuroscience, Rank: 37.3%]


12) Physicians’ recognition of end of life may influence patients’ good death.
Chaoming Huang, Sheng-Jean Huang, Tai-Yin Wu, Yen-Ching Chen, Sheng-Huang Hsiao, Dachen Chu. Physicians are over optimistic in recognizing inpatients’ survival and palliative care needs: A large scale multi-center study in Taiwan. QJM: An International Journal of Medicine, hcad246 (October 2023). [Medicine, General & Internal, Rank: 6.5%]

13) Association between baseline retinal vascular structure and the risk of cognitive impairment over time Ting-Yu Wu, Yi-Ting Hsieh, Yu-Hsin Wang, Jeng-Min Chiou, Ta-Fu Chen, Liang-Chuan Lai, Jen-Hau Chen, Yen-Ching Chen. The Association between Retinal Vascular Fractal Dimension and Cognitive Function in The Community-dwelling Older Adults Cohort TIGER. Journal of Formosan Medical Association. 122(10): 1050-1060 (October 2023). [Medicine, General & Internal, Rank: 21.4%]

14) First study exploring interaction of exposure to ambient air pollutants and indoor air quality on cognition of older adults (using multi-pollutant model considering collinearity among pollutants) 4 Yen-Ching Chen, Pei-Iun Hsieh, Jia-Kun Chen, Emily Kuo, Hwa-Lung Yu, Jeng-Min Chiou, Jen-Hau Chen. Effect of indoor air quality on the association of long-term exposure to low-level
air pollutants with cognition in older adults. Environmental Research 233(15): 115483
(September 2023). [Public, Environmental & Occupational Health, Rank: 4.8%]


15) Robot development for dementia patients
Yu-Lin Zhao, Han-Pang Huang, Pen-Chi Chiang, Huai-Te Wang, Jen-Hau Chen, Yen-Ching Chen. Development of robots for people with dementia: Technologies and applications. Journal of the Chinese Society of Mechanical Engineers. 44(4):351-360 (August 2023). [Engineering, Mechanical, Rank: 97%]

16) A long-term cohort study on the association of preclinical depression, sleep and cognition in community-dwelling older adults Ching-Jow Hsieh, Jeng-Min Chiou, Ta-Fu Chen, Yen-Ching Chen, Jen-Hau Chen. Association of subclinical depressive symptoms and sleep with cognition in the communitydwelling older adults. Journal of Formosan Medical Association 122(8): 7990-799 (August 2023). [Medicine, General & Internal, Rank: 21.4%]

17) Repeated measures on dietary quality (3

trajectories) in relation to cognition of older adults Ling-Wei Chen, Yi-Chun Chou, Meei-Shyuan Lee, Jeng-Min Chiou, Jen-Hau Chen, Yen-Ching
Chen. Longitudinal trajectories of dietary quality and cognitive performance in older adults: Results from a 6-year cohort study. Clinical Nutrition 42(6): 879-886 (June 2023). [Nutrition & Dietetics, Rank: 9.3%]

18) Longitudinally predicting the risk of cognitive impairment using grip strength and sarcopenia Tao-Chun Peng, Jeng-Min Chiou, Ta-Fu Chen, Yen-Ching Chen, Jen-Hau Chen. Grip strength and sarcopenia predict 2-year cognitive impairment in community-dwelling older adults. Journal of the American Medical Directors Association 24(3): 292-298.e1 (March 2023). [Geriatrics & Gerontology, Rank: 23.6%]

19) Active survey can identify more early dementia than passive screening Yun-Ru Lu, Tzy-Haw Wu, Yachung Jeng, Wen-Yuan Lee, Wei-Chih Hsu, Amy Ming-Fang Yen, Shin-Liang Pan, Yen-Ching Chen, Sam Li-Sheng Chen, Hsiu-Hsi Chen, Horng-Huei Liou. The
impact of active community-based survey on dementia detection ratio in Taiwan: A cohort study
with historical control. Frontiers in Public Health 10:1005252 (January 2023). [Public,
Environmental & Occupational Health, Rank: 28.1%]


20) First study on sex-specific multimorbid patterns related to cognition in Taiwanese older
adults (accounting for the effect of informative dropout)
Pei-Iun Hsieh, Yen-Ching Chen, Jeng-Min Chiou, Jen-Hau Chen. Multimorbid patterns and cognitive performance in the presence of informative dropout among community-dwelling Taiwanese older adults. Innovation in Aging 7(2): 1-13 (February 2023). [Gerontology, Rank: 3.2%]

21) A review for instruments assessing the burden of dementia caregivers Jennifer Young Tu, Grace Jin, Jen-Hau Chen, Yen-Ching Chen. Caregiver burden and dementia: A systematic review of self-report instruments. Journal of Alzheimer’s Disease 86(4):1527-1543 (March 2022). [Neuroscience, Rank: 37.3%] 5

22) The first study exploring extended definitions of cognitive frailty combining frailty dimensions and cognitive domains Jen-Hau Chen, Hua-San Shih, Jennifer Tu, Jeng-Min Chiou, Shu-Hui Chang, Wei-Li Hsu, LiangChuan Lai, Ta-Fu Chen, Yen-Ching Chen. Longitudinal study on the association of interrelated
factors among frailty dimensions, cognitive domains, cognitive frailty and all-cause mortality.
Journal of Alzheimer’s Disease 84(4):1795-1809 (December 2021). [Neuroscience,
Rank:37.3%]


23) A community-based cohort study on the association between metabolic syndrome and
successful aging
Yi-Hsuan Lin, Jeng-Min Chiou, Ta-Fu Chen, Liang-Chuan Lai, Jen-Hau Chen, Yen-Ching Chen. The association between metabolic syndrome and successful aging- using an extended
definition of successful aging. PLoS ONE 16(11): e0260550 (December 2021).
[Multidisciplinary Science, Rank: 23.5%]


24) Long-term exposure to air pollutants (estimated by Bayesian maximum entropy) in relation
to cognitive function in older adults – A prospective cohort study
Jen-Hau Chen, Tsung-Yu Kuo, Hwa-Lung Yu, Charlene Wu, Su-Ling Yeh, Jeng-Min Chiou, TaFu Cheng, Yen-Ching Chen. Long-term exposure to air pollutants and cognitive function in Taiwanese community-dwelling older adults: A four-year cohort study. Journal of Alzheimer’s Disease 78(4), 1585-1600 (November 2020). [Neuroscience, Rank: 37.3%]

25) The effect of chronic renal disease and cortical thinning (neurodegeneration) on cognitive function Chih-Hao Chen, Ya-Fang Chen, Ping-Huan Tsai, Jeng-Min Chiou, Liang-Chuan Lai, Ta-Fu Chen, Hung Hung, Jen-Hau Chen, Yen-Ching Chen*. Impacts of kidney dysfunction and cerebral
cortical thinning on cognitive change in elderly population. Journal of Alzheimer’s Disease 76(1):
225-236 (May 2020). [Neuroscience, Rank: 37.3%]